ALVIN L. CRUMBLISS
Professor, Department of Chemistry

Contact Information
312 P.M. Gross Chemical Laboratory
(PH) 919-660-1540
(FX) 919-660-1605
alvin.crumbliss@duke.edu

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Education

	PhD	A Study of Some Oxygen, Tetracyanoethylene and Tetraflurooethylene Adducts of Bis(acetylacetone)ethylenediiminecobalt(II), Inorganic Chemistry, Northwestern University, Evanston, IL, 1968
	AB	Chemistry, Knox College, Galesburg, Illinois, 1964

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Experience

	1970-present	Assistant, Associate, Professor of Chemistry, Duke University
	1998-2001	Canvassing Committee, ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry
	1998-present	Executive Committee, North Carolina Section, American Chemical Society Councilor, American Chemical Society
	1999	Professeur Associé, Université J. Fourier de Grenoble, France Troisieme Cycle Lecturer, Inorganic Chemistry, Switzerland
	1996	Professeur Associé, Université J. Fourier de Grenoble, France
	1995	Professeur Invité, Chaire Elf - Académie des Sciences, ENSCP de Paris, France
	1995	Professeur de l’Académie, Chaire Elf - Académie des Sciences, Ecole Européenne des Hautes Etudes des Industries Chimiques de Strasbourg, France
	1991-1994	Chairman, Department of Chemistry, Duke University Professeur d'Echange, Université Paris-Sud, Orsay, France
	1985	Senior Visitor, Inorganic Chemistry Laboratory, Oxford University, U.K. Professeur d'Echange, Université Paris-Sud, Orsay, France
	1979-1982	Director of Undergraduate Studies in Chemistry
	1978	Visiting Scientist, Université Paris-Sud, Orsay, France
	1968-1970	Postdoctoral Research Associate, University of Southern California
	1964	Chemist, Borg-Warner Research Center, Des Plaines, IL

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Selected Publications

1. “The Influence of the Synergistic Anion on Iron Chelation by Ferric Binding Protein, A Bacterial Transferrin” S. Dhungana, C. H. Taboy, D. S. Anderson, K. G. Vaughan, P. Aisen, T. A. Mietzner, and A. L Crumbliss, Proc. Natl. Acad. Sci. (USA), 100, 3659 (2003).
2. “Chemical Aspects of Siderophore Mediated Iron Transport” H. Boukhalfa and A. L. Crumbliss, BioMetals, 15, 325 (2002).
3. “Crystal Structure of Ferrioxamine B: A Comparative Analysis and Implications for Molecular Recognition” S. Dhungana, P. S. White, and A. L. Crumbliss, J. Biol. Inorg. Chem., 6, 810 (2001).
4. “The Use of SDS Micelles to Stabilize a Ternary Intermediate in the Reaction of Ferrioxamine B and 1,10-Phenanthroline” E. G. Olmstead, Jr., P. L. Choo, S. W. Harman and A. L. Crumbliss, Inorg. Chem., 40, 5420 (2001).
5. “pH Induced Active ("Uphill") Liquid Membrane Transport of Ferrioxamine B by the Ionizable Ionophore Lasalocid” I. Spasojevic and A. L. Crumbliss, Inorg. Chem., 38, 3248 (1999).
   
   

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Synergistic Activities

• Organizing Committee, International Conference on BioIron, 1994-95
• Chairman, North Carolina Section, American Chemical Society 1989
• Board of Expert Analysts, CHEMTRACTS - Inorganic Chemistry, 1992–present
• Ad Hoc Task Force to Monitor Accounts of Chemical Research, 1994 – 95
• Editorial Advisory Board, Inorganic Chemistry, 1999–2002
• Editorial Advisory Board, BioMetals, 2000–2003
• Board of Directors, JEPA-LIMMAT Foundation, Zurich, Switzerland, 2001 – present
  

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Industrial Consulting

Institutional Review Board, ClinDAR, Inc., 1984-1986; Consultant, Monsanto, St. Louis, MO, 1987; Science Advisory Board, Enzyme Technology Research Group, Inc., 1987-89; Consultant, Syntex, Inc., 1988-1989; Consultant, AndCare, Inc, 1990–1992; Technology Advisory Board, Corpex Technologies, Inc., 1994–97; Consultant, Frommer, Lawrence & Haug LLP, 2002; Consultant, CHARAK, LLC, 1999 -present

Postdoctoral Scholars (PS) Supervised Over Past 5 Years:
I. Batinic-Haberle, PhD (PS), H. Boukhalfa PhD (PS), Mario Gabricevic (PS).

Graduate Students (GS) Supervised Over Past 5 Years:
C.D. Caldwell, PhD (GS), D.C. Kraiter, PhD (GS), E. Olmstead, PhD (GS), L. Lowry, MA (GS), I. Spasojevic, PhD (GS), C. Taboy, PhD (GS), S. Trzaska, PhD (GS).

Current graduate students:
S. Dhungana, M. Flaherty, K. Meis, K. Weaver, and J. Wirgau.

Current postdoctoral scholar:
Mario Gabricevic, PhD

Total Number Students Supervised:
Grad students: 36; Postdoctoral scholars: 7

Research Support:

• Dr. Crumbliss is PI on 2 active grants: National Science Foundation: Grant #CHE-0079066. American Chemical Society Petroleum Research Fund: Grant # 34622-AC3.
• Dr. Crumbliss is a Co-PI on 2 active grants: National Institutes of Health: Grant # HL58248. Department of Energy: Grant # DE-FG02ER63321.
• Dr. Crumbliss is a Co-PI on 1 proposal pending: National Institutes of Health.
  

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Short Research Interest Description

The chemistry of metal ion transport, speciation, and reactivity in biological systems.

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Research Interest

Current research interests emphasize the role of metals in biological systems, and their reactivity, speciation and mobility. This includes ion and molecular recognition, non-covalent interactions and membrane transport. Ongoing research projects include: thermodynamics, kinetics and mechanism of Fe(III) chelation/dechelation and redox reactions, particularly as they relate to siderophore mediated microbial iron bioavailability and protein mediated iron transport in mammals and bacteria; the influence of the second coordination sphere on transition metal complex reactivity and molecular recognition; spectroelectrochemistry; supramolecular assemblies and membrane transport processes; and reactivity and cooperativity in hemoglobins.

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