ANNE LAZARIDES
Assistant Professor
Dept. of Mechanical Engineering and Materials Science

Contact Information
3395 CIEMAS
CBIMMS, Box 90300
(PH) 919-660-5483
(FX) 919-660-5409
aal@duke.edu

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Education

	PhD	Quantitative methods for evaluating microscopic and macroscopic collision observables for their usefulness in refining models of few atom systems, Chemistry, Princeton University
	BS	Applied Mathematics, Yale University

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Experience

	2002-present	Assistant Professor, Mechanical Engineering and Materials Science, Duke University
	2000-2002	Research Assistant Professor, Chemistry, Institute for Nanotechnology and Center for Nanofabrication and Molecular Self-Assembly, Northwestern University
	1997-2000	Northwestern University, Chemistry
	1993-1997	Xerox Center for Research and Technology, Condensed Matter Physics

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Selected Publications

1. Park, S.-J.; Lazarides, A. A.; Storhoff, J. J; Pesce, L.; Mirkin, C. A. ?Structural Characterization of Oligonucleotide-Modified Gold Nanoparticle Networks Formed by DNA Hybridization? J. Phys. Chem. B 2004 (in press).
2. Denisov, I. G.; Grinkova, Y. V.; Lazarides, A. A.; Sligar, S. G. “Directed Self-Assembly of Monodisperse Phospholipid Bilayer Nanodiscs with Controlled Size” J. Am. Chem. Soc. 2004, 126(11), 3477-3487.
3. Park, S.-J.; Lazarides, A. A.; Mirkin, C. A.; Letsinger, R. L. “Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks” Angew. Chem. Int. Ed. 2001, 40, 2909-2912.
4. Storhoff, J. J.; Lazarides, A. A.; Mucic, R. C.; Mirkin, C. A.; Letsinger, R. L.; Schatz, G. C. “What Controls the Optical Properties of DNA-linked Gold Nanoparticle Assemblies?” J. Am. Chem. Soc. 2000, 122, 4640-4650.
5. Lazarides, A. A.; Schatz, G.C., “DNA-linked Metal Nanosphere Materials: Structural Basis for the Optical Properties” J. Phys. Chem. 2000, 104, 460-467.
6. Lazarides, A.A.; Kelly, K.L.; Jensen, T.R.; Schatz, G.C., ?Optical Properties of Metal Nanoparticles and Nanoparticle Aggregates Important in Biosensors? Theochem, 2000, 529, 59-63.
7. Jensen, T.R.; Duval, M.L.; Kelly, K.L.; Lazarides, A. A.; Schatz, G.C.; Van Duyne, R.P. ?Nanosphere Lithography: Effect of the External Dielectric Medium on the Surface Plasmon Resonance Spectrum of a Periodic Array of Silver Nanoparticles? J. Phys. Chem. B 1999, 103, 9846-9853.
8. Park, S.-J.; Lazarides, A. A.; Mirkin, C. A.; Braziz, P. W.; Kannewurf, C. R.; Letsinger, R. L. ?The Electrical Properties of Gold Nanoparticle Assemblies Linked by DNA? Angew. Chem. Int. Ed. 2000, 39, 3845-3848.
9. Lazarides, A.A.; Kelly, K.L.; Schatz, G.C., ?Effective Medium Theory of DNA-linked Gold Nanoparticle Aggregates: Effect of Aggregate Shape? MRS Fall 2000 Symposium C Proceedings 2001.
10. Lazarides, A. A.; Schatz, G.C. ?DNA-linked Metal Nanosphere Materials: Fourier Transform Solutions for the Optical Response? J. Chem. Phys. 2000, 112, 2987-2993.
11. Lazarides, A. A., Duke, C. B.; Paton, A.; Kahn, A. ?Determination of the Surface Atomic Geometry of PbTe(100) by Dynamical Low-energy Electron Diffraction Intensity Analysis? Phys. Rev. B. 1995, 52, 14895-14905.
12. Lazarides, A. A.; Rabitz, H.; McCourt, F. R. W. “A Quantitative Technique for Evaluating the Usefulness of Experimental Data in Refining a Potential Surface” J. Chem. Phys. 1994, 101, 4735-4749.

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Short Research Interest Description

Optical signaling in biofunctionalized nanostructures, self-assembled materials, and integrated nanosystems. Applications include ultrasensitive molecular detection and photodetection systems.

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Research Interest

Our goals are to understand how nanoscale structure controls the static and dynamic properties of hybrid bio/inorganic materials and to use this knowledge to design nanostructures and materials with useful properties. We develop theoretical tools to predict properties of nanostructures from properties of the components given structural models and then use these tools both for nanostructure design and for interpretation of experimental measurements of nanoscale structure and of optical properties. We are interested as well in the forces that control nanostructure organization and in the design of model systems that can be used to understand nanocomponent aggregation in naturally occurring assembly processes. We are also involved in developing modern methods of characterizing nanostructures so as to enable us to monitor their assembly and engineer their growth. Examples of the types of systems in which we are interested include

• Metal nanoparticles and nanoparticle assemblies of use in biomolecule detection. Metal nanoparticles have optical resonances that are highly sensitive to the particle environment and that can be used to detect changes in the environment, such as variations in the dielectric properties of near surface exterior due to biomolecule binding or the assembly of other conductive components in the local environment. We are interested in understanding how the optical behavior of nanoparticles and nanoparticle assemblies depends upon the composition and structure of the particles and local biomatter and upon the structure of the exciting light. We are using this understanding to design nanopatterned self-assembling surface systems that serve as platforms for ultrasensitive biomolecule detection.

• Protein-scaffolded lipid bilayer nanodisks that provide a controllable environment for membrane proteins. Small angle x-ray scattering provides a means of detecting the nanoscale structure of disks containing single membrane proteins and protein/ ligand pairs and dynamically tracking protein/ligand assembly. While the experimental data is on protein populations, rather than single molecules, the confinement provided by the disks eliminates the environmental heterogeneity that typically is present among membrane proteins in liposomes.

• Nanoparticle model systems for naturally-occurring biomolecule induced aggregation. Many important natural processes in bodies of water such as cycling of elements, biomineralization, and trace metal transport are controlled by nanoscale components and biopolymers. We develop model system components with appropriate biomimetic surface chemistries and use them to examine the dependence of important naturally occurring interactions and processes on variations in environmental variables. Our goals are to better understand the properties of the organic and inorganic components that control templating, aggregation, and metal scavenging processes in natural waters.

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