LORI SETTON
Harold L. Yoh Faculty Scholar
Associate Professor, Department of Biomedical Engineering

Contact Information
B222 Levine Science Research Center
919-660-5131
919-660-5362
setton@duke.edu

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Education

	PhD	Effects of Intrinsic Viscoelasticity and Ion-Induced Swelling on the Mechanical Behaviors of Articular Cartilage, Mechanical Engineering, Columbia University, 1993
	MS	Mechanical Engineering, Columbia University, 1988
	BSE	Mechanical and Aerospace Engineering, Cum Laude, Princeton University, 1984

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Experience

	2001-present	Associate Professor, Department of Biomedical Engineering, Duke University, NC
	1996- present	Assistant Professor (secondary appointment), Department of Mechanical Engineering, Duke University, NC
	1995-2001	Assistant Professor, Department of Biomedical Engineering, Duke University, NC
	1995-present	Assistant Research Professor (secondary appointment), Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, NC
	1995-present	Member, Center for Cellular and Biosurface Engineering, Duke University, NC
	1993-1994	Associate Research Scientist, Orthopaedic Research Laboratory, Columbia University, NY
	1987-1993	Staff Associate, Orthopaedic Research Laboratory, Columbia University, NY

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Selected Publications

1. Baer AE, Laursen TA, Guilak F and Setton LA (2003): The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. Journal of Biomechanical Engineering 125:1-11.
2. Betre H, Setton LA, Meyer DE and Chilkoti A (2002): Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair. Biomacromolecules 3:910-916.
3. LeRoux MA and Setton LA (2002): Experimental and biphasic FEM determinations of the material properties and hydraulic permeability of the meniscus in tension. Journal of Biomechanical Engineering 124:315-321.
4. Elliott DM and Setton LA (2001): Anisotropic and inhomogeneous tensile behavior of the human anulus fibrosus: Experimental measurement and material model predictions. Journal of Biomechanical Engineering, 123:256-263.
5. Narmoneva DA, Wang JY, Setton LA (2001): A non-contacting method for material property determination for articular cartilage from osmotic loading. Biophysical Journal 81: 3066-3076.
   

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Selected Honors and Awards

Outstanding Research Award, Pratt School of Engineering, Duke University, 2001; Yoh Faculty Scholar, Duke University, 1998; Presidential Early Career Award for Scientists and Engineers (PECASE), 1997; Delegate, National Academy of Engineering 2nd Annual Symposium on “Frontiers of Engineering,” Irvine, CA 1996.

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Selected Synergistic Activities

Associate Editor, Journal of Biomechanical Engineering (2000-present); Editorial Consultant, Journal of Biomechanics (1998-present); Permanent Member, NIH Orthopaedic Study Section (2001-present); Member, World Council on Biomechanics, 2002-2005; Panelist on Mentoring, Symposium on the Advanced Degree & Science/Engineering Education (2000).

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Collaborators

Farshid Guilak; Ed Hsu; William Kraus; William Richardson; T. Parker Vail; Ashutosh Chilkoti; Mark Grinstaff; Yefu Li (Harvard School of Dental Medicine); Bjorn R. Olsen (Harvard Medical School); Sergio Jimenez (Thomas Jefferson University)

Thesis Advisor (completed)
Dawn Elliott, Michelle LeRoux, Daria Narmoneva, Anthony Baer

Thesis Advisor (current)
Maureen Upton, Helawe Betre, Larry Boyd, Chris Gilchrist, Dana Nettles

Research Support
Dr. Setton is a PI on 2 active grants: 2 NIH RO1 grants. She is a Co-Investigator on 3 grants: 1 NIH PPG grant, 1 Orthopaedic Research and Education Foundation grant, and 1 Arthritis Foundation grant.

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Short Research Interest Descriptor

Functional tissue engineering and mechanobiology of cartilaginous tissue repair.

 

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Research Interest

Research in the Laboratory focuses on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus. Work in the Laboratory is focused on material characterization of native and healing biological tissues as well as tissue engineered biomaterial constructs. Studies combining engineering and biology are also used to determine the role of mechanical factors to promote and control healing of cartilaginous tissues.

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